A Cancer Stem Cell Models as the Point of Origin of Cells in Tumor Microenvironment-World’s First Finding in Cancer Research Using iPS Cells

July 28(Fri), 2017

A team of researchers of the Lab of Nano-Biotechnology at the Department of Biotechnology, Graduate School of Natural Science and Technology, Okayama University, led by Professor Masaharu Seno and Senior Research Assistant Professor Tomonari Kasai has found that CSCs are a source of CFA (cancer associated fibroblast). They exposed the mouse induced pluripotent stem cells to the conditioned medium prepared from the culture of human breast cancer cell line and induced them to cancer stem cells. The resulting CSC cells have developed into CAF.

Cancer tissues are composed of cancer cells and various interstitial cells that surround the cancer cells. CAF, an interstitial cell, in particular, shares the largest amount of the cellular components that compose interstitial tissue of solid cancer. Recent studies have revealed that CAF creates microenvironment for cancer. Under the environment, CFA produces various growth factors that contribute to growth promotion of cancer cells. Though this interaction between cancer cells and CAF has been given priority to be investigated, where CFA originates from has yet to be discovered.

This, a world first finding, is the result of the attempt to artificially create cancer stem cell with the team’s original method using iPS cells, without any modification such as gene mutation, insertion or deletion. The output of the research will be published with an internationally acclaimed scientific journal, Scientific Reports on July 28th (published online: 28 July).

The research output stemmed from the finding that cancer stem cells induced from iPS cells differentiated into myofibroblasts. The team analyzed the cells to reveal that they satisfy the characteristics of CAF, which have already been reported. Cancer stem cells as a source of CAF differentiate into CAF and create the “niche” microenvironment for cancer cells to accelerate self-reproduction of the stem cells.

Cancer is a life threatening disease with high mortality rate. The research output is expected to contribute to the evolution of cancer and treatment research as well as to show the direction that new researches should take.


Article Information

DOI: 10.1038/s41598-017-07144-5

Journal: Scientific Reports

Title: A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment

Authors: Neha Nair, Anna Sanchez Calle, Maram Hussein Zahra, Marta Preito-Villa, Aung Ko Ko Oo, Laura Hurley, Arun Vaidyanath, Akimasa Seno, Junko Masuda, Yoshiaki Iwasaki, Hiromi Tanaka, Tomonari Kasai, Masaharu Seno

Year of Publication: 2017

Volume: 7


Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067

E-mail:    ousvo@okayama-u.ac.jp



CSC, CAF, iPS cells, cancer stem cell

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