A successful examination of the photointermediates of proteins through light irradiation NMR technology – Helped to understand the dynamic structural changes of proteins utilizing lights
July 04(Wed), 2018
A collaborative research group led by Akira Naito, an emeritus professor, Izuru Kawamura, an associate professor, Kazuyoshi Ueda, a professor, and Yoshiteru Makino, Ph.D. at Yokohama National University, Yuki Sudo, a professor at Okayama University, Akimori Wada, a professor, and Takashi Okitsu, an instructor at Kobe Pharmaceutical University, and Naoki Kamo, an emeritus professor at Hokkaido University, discovered the structure of the retinal of multiple photointermediates produced by photorhodopsin, one of the rhodopsin proteins, after light absorption. Light-irradiating nuclear magnetic resonance (NMR) equipment was used for this discovery. Through this research, it is expected that the dynamic structural changes that are necessary for proteins to express their functions will be revealed.
This research result was published in Volume 115 (1) (July 3, 2018, U.S. time) of the Biophysical Journal, an American biophysical journal, and it was noted on the cover of that issue. This research was conducted with financial support from Scientific Research (B) and Scientific Research (C), the New Research Projects, the Research Fellowship for Young Scientists of the Grants-in-Aid for Scientific Research, CREST, and AMED of The Japan Society for the Promotion of Science.
Journal: Biophysical Journal
Authors: Yoshiteru Makino, Izuru Kawamura, Takashi Okitsu, Akimori Wada, Naoki Kamo, Yuki Sudo, Kazuyoshi Ueda, Akira Naito
Title: Retinal Configuration of ppR Intermediates Revealed by Photoirradiation Solid-State NMR and DFT
Year of Publication: 2018 Volume: 115 Issue: 1
Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.