An important role of the macropharge receptor in immune responses to Helicobacter pylori infections
March 22(Thu), 2018
The collaborative research group consisting of Kenji Yokota, Professor (Bacteriology and Infection Immunity) at the Graduate School of Health Science, Hiroyuki Okada, Professor (Department of Gastroenterology and Hepatology), and Osamu Matsushita, Professor (Department of Bacteriology) at the Graduate School of Medicine, Dentistry, and Pharmaceutical Science, of Okayama University found that one of the marcropharge receptors, DEC205, has an important role in systemic immunity under Helicobacter pyloriinfections. This research finding is expected to be published in the British online journal “Oncotraget” on February 26, 2018.
It has been reported that H. pylorinot only infects the stomach, but also affects systemic immunity and causes some systemic diseases. There is nomucosa-associated lymphoid tissue (MALT) in the mucosa of a stomach, but it was found that the macropharge which infiltrates through the epithelium of the mucosa can recognize H. pylori. It also became clear that the patients’ macropharges that directly react to H. pylori throughout their bodies. These findings will help with understanding H. pyloriassociated diseases in the future.
Authors: Masahide Kita, Kenji Yokota, Chihiro Kageyama, Susumu Take, Kazuyoshi Goto, Yoshiro Kawahara, Osamu Matsushita, Hiroyuki Okada
Journal:Oncotarget in press
Title: DEC205 mediates local and systemic immune responses to Helicobacter pylori infection in humans
Year of Publication:2018
Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.