Discovery and targeting of cancer progression factors from exosomes secreted by oral cancer cells
May 31(Thu), 2018
An international research group consisting of Kisho Ono, DDS, Takanori Eguchi, DDS, PhD, and colleagues at Okayama UniversityGraduate School and Dental School, Junya Futagawa at Mitsui Knowledge Ind., and Stuart K Calderwood, PhD at Harvard Medical School developed exosome-proteomics, by which this team discovered novel prognostic biomarkers and therapeutic targets from exosomes (also known as extracellular vesicles, EVs) secreted by metastatic oral cancer cells. These research products were published in the Journal of Cellular Biochemistryon May 16, 2018.
In this study, it was discovered that exosomes secreted by oral cancer cells with highly metastatic traits abundantly contained heat shock proteins (HSP) that can protect cancer cells. The HSPs revealed in this study can be applied as novel prognostic biomarkers contained in exosomes to medical practice.
Authors: Kisho Ono, Takanori Eguchi, Chiharu Sogawa, Stuart K Calderwood, Junya Futagawa, Tomonari Kasai, Masaharu Seno, Kuniaki Okamoto, Akira Sasaki and Ken-ichi Kozaki
Journal: Journal of Cellular Biochemistry
Title: HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells
Year of Publication:May 2018
Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.