Discovery of a mechanism that promotes proper bone formation by resident microbiota
September 27(Thu), 2018
A research group at Okayama University consisting of Yoko Uchida, a graduate student, and Manabu Morita, a professor at the Oral Health Division of the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Koichiro Irie, a researcher at Columbia University in the U.S., Mitsuaki Ono, an assistant professor at the Molecular Biology and Biochemistry Division of the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Takako Hattori, an associate professor, and Satoshi Kubota, a professor in the Biochemistry and Molecular Dentistry Division of the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences at Okayama University, found that the existence of resident microbiota activates osteoblasts and osteoclasts, which control the metabolism of bones.
The group discovered that the bone frames of regular mice with resident microbiota were much larger than the bone frames of germ-free mice whose resident microbiota was artificially removed. On the other hand, it became clear that the bones of the germ-free mice were excessively calcified. The regular mice with the resident microbiota retained many activated osteoclasts. Also, in the examination of the osteoblasts isolated from the regular mice with the resident microbiota, the group noted that the expression of osteocalcin genes that control calcification was enhanced. This research suggests that microbiota induces epigenetic changes to osteoblasts and controls the expression of genes. In addition, microbiota seems to promote bone formation and bone metabolism, as well as promoting immunological responses. This research finding was published in Swiss peer-reviewed scientific journal “Molecules” on June 23, 2018.
Authors: Yoko Uchida, Koichiro Irie, Daiki Fukuhara, Kota Kataoka, Takako Hattori, Mitsuaki Ono, Daisuke Ekuni, Satoshi Kubota and Manabu Morita
Title: Commensal microbiota enhance both osteoclast and osteoblast Activities
Year of Publication: 2018
Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.