Discovery of a molecule that promotes bone healing and controls inflammatory response after a tooth extraction

March 22(Thu), 2018

Mr. Hiroaki Aoyagi, a graduate student; Asst. Prof. Keisuke Yamashiro, Prof. Shogo Takashiba, Professor (Department of Pathophysiology-Periodontal Science); and Prof. Masahiro Nishibori, Professor (Department of Pharmacology) at the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University;

discovered that HMGB1 (High Mobility Group Box 1), a non-histone DNA-binding protein secreted into the extracellular milieu in response to inflammatory stimuli, plays critical role in bone healing process after tooth extraction.

This research was published in the British science journal “Journal of Cellular Biochemistry” on January 27, 2018.

In this study, research group focused on the HMGB1 secreted around tooth extraction socket, the tissue containing gingival epithelium, and alveolar bone; aiming to determine its role in bone healing after tooth extraction. They constructed a murine tooth extraction model with anti-HMGB1 neutralization antibody administration and observed the inflammatory response and bone healing process in tooth extraction sockets. They noticed that the translocation of HMGB1 from the nucleus to the cytoplasm in gingival epithelial cells and inflammatory cells was inhibited by anti-HMGB1 antibody administration, and as a result, the level of inflammation after tooth extraction was reduced. This further delayed regeneration of blood vessels and bones, and the healing process after a tooth extraction was prolonged.

These results suggest that, HMGB1 regulate initial inflammatory response needed for bone healing and regeneration in tooth extraction socket. From this research, future application of anti-inflammatory drugs to block HMGB1 can be anticipated.

Article Information


Authors: Hiroaki Aoyagi, Keisuke Yamashiro, Chiaki-Hirata Yoshihara, Hidetaka Ideguchi, Mutsuyo Yamasaki, Mari Kawamura, Tadashi Yamamoto, Shinsuke Kochi, Hidenori Wake, Masahiro Nishibori, Shogo Takashiba

Journal:Journal of Cellular Biochemistry

Title: HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket.

Year of Publication:Jan 27, 2018


Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067



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