Discovery of a treatment that boosts the effectiveness of the neural stem cell transplantation after spinal injury! ‐ A new treatment for spinal injuries anticipated –

March 09(Fri), 2018

Kinichi Nakashima, Professor of the Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences at Kyushu University, and Naohiro Uezono, a fourth year graduate student at the Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences at Kagoshima University, together collaborated on research with the team of Masahiro Nishibori, Professor at the Department of Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences of Okayama University, on mice to discover the effectiveness of the HMGB1 antibody during the acute stage of a spinal cord injury. When the HMGB1 antibody is administered during the acute period of a spinal cord injury of a mouse, it controls the blood-spinal cord barrier permeability, and reduces the ensuing spinal cord edema formation. By this administration, an injured region can be controlled so that it will not become larger, and it minimizes death of the interneurons (nerve cells) around the injured spinal cord. The procedure was examined, and it was found to be beneficial for the later rebuilding of neural circuits and the recovery of hindlimb movement functions.

In addition to the antibody treatment during the acute stage of a spinal injury, a transplantation of human induced pluripotent stem cells (“hips-NSCs”) was conducted, which showed even more dramatic treatment effectiveness together, rather than administered alone. It has been reported that neurons that are differentiated from transplanted cells becomes a part of rebuilt neural circuits and contribute directly to the recovery of movement functions. This research shows the further effectiveness of treatment in which the antibody treatments are setting up the environment around the injured spinal cords to give more opportunities to the transplanted neural stem cell (NSC)‐derived neurons to form synapses that lead to recovery of movement functions (Chart 1). This accomplishment gives hope to a new treatment of spinal injuries.

This research result was published in the online version of “Stem Cells,” an international peer reviewed journal at 11 a.m. (EST in the U.S.) on Thursday, March 8, 2018.

Article Information


Authors: Naohiro Uezono , Yicheng Zhu, Yusuke Fujimoto, Tetsuro Yasui, Taito Matsuda, Masahide Nakajo, Masahiko Abematsu, Takao Setoguchi, Shuji Mori,

Hideo K. Takahashi, Setsuro Komiya, Masahiro Nishibori, Kinichi Nakashima

Journal:Stem Cells

Title: Prior Treatment with Anti‐High Mobility Group Box‐1 Antibody Boosts Human Neural Stem Cell Transplantation‐Mediated Functional Recovery After Spinal Cord Injury

Year of Publication:March 8, 2018


Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067



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