Discovery of PM Proteins in the Atmosphere Receiving Chemical Modifications of Tyrosine Nitration Through Reaction with Ozone and Nitrogen Oxides Known as Asthma Causing Pollutants

November 15(Wed), 2017

A research group lead by Keiki Ogino, Professor, and Tatsuo Ito, Assistant Professor at the Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, discovered that proteins in particulate matter (“PM”) in the atmosphere receive chemical modifications through a reaction with ozone and nitrogen dioxide. This discovery was published in the British science magazine “Environmental Pollution” on November 10, 2017.
It has been pointed out that the concentration of particulate matter in the atmosphere is related to respiratory and cardiovascular diseases.
There are various types of protein-containing materials, such as pollen, viruses and fungi, which are bound together with particulate matter and float in the atmosphere. There have been reports published about how a chemical modification of tyrosine nitration in allergen proteins worsened allergies, but all the experiments had been conducted in man-made spaces. In this research, under high humidity conditions, the researchers discovered that the generation of nitrotyrosine was related to ozone, nitrogen oxides and floating PM in the atmosphere.
The results of this research will provide important knowledge for measuring health effects caused by particulate matter in the atmosphere.


Article Information

DOI: 10.1016/j.envpol.2017.10.069.

Authors: Tatsuo Ito, Keiki Ogino, Kenjiro Nagaoka, and Kei Takemoto

Journal: Environmental Pollution 

Title: Relationship of particulate matter and ozone with 3-nitrotyrosine in the atmosphere

Year of Publication: 2017


Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067



PM Proteins in the Atmosphere, Tyrosine Nitration, ozone, respiratory, cardiovascular diseases,

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