Discovery of Specific MicroRNA in Saliva of Patients with Pancreatobiliary tract cancer: Possible Early Detection of Pancreatobiliary tract cancer with Saliva Examination
September 28(Thu), 2017
The collaborative research group of Professor Manabu Morita of the Department of Preventive Dentistry, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Assistant Professor Takayuki Maruyama of the Center for Innovative Clinical Medicine, Professor Hiroyuki Okada of the Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences et al. discovered that the expression levels of miR-1246 and miR-4644, types of microRNA, are higher in saliva of patients with Pancreatobiliary tract cancer than those of healthy control participants. This research result was published in the British online journal Oncology Reports on August 12, 2016.
Pancreatobiliary tract cancer tends to produce little or no subjective symptoms and is not found until the symptoms progress, which often leads to poor prognosis. Therefore, development of biomarkers that enable early cancer detection is desired. This research result is expected to promote the possibility of early detection of pancreatobiliary tract cancer with saliva tests.
Journal: Oncology Reports
Title: miR-1246 and miR-4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer
Authors: Tatsuya Machida, Takaaki Tomofuji, Takayuki Maruyama, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Hisataka Miyai, Hirofumi Mizuno, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Hiroyuki Okada, Manabu Morita
Year of Publication: 2017
Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.
- microRNA, saliva, cancer