Discovery of the Body’s Internal Clock Being an Important Factor in Maintaining the Blood-brain Barrier

September 28(Thu), 2017

A collaborative research group consisting of Takeshi Takarada, Associate Professor at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences (Med.), Kanazawa University, and Nihon University has made a discovery. The research group found that deficiencies in the components of the human body’s circadian clock system cause pericytes in the blood vessels around the brain to malfunction, and that this dysfunction weakens the body’s function to maintain homeostasis. This finding was published as a research article in the Journal of Neuroscience, an international science magazine, on September 14th.

Several central nervous system diseases are known to cause sleep disorders. This research proposed a theory that states that the components of the circadian clock that are responsible for the sleep-wake rhythm are an important factor in maintaining homeostasis in the cerebral blood vessels. This result is expected to provide additional knowledge to help understand the pathology of central nervous system diseases.


Article Information

DOI: 10.1523/JNEUROSCI.3639-16.2017

Journal: Journal of Neuroscience

Title: Disruption of Bmal1 impairs blood-brain barrier integrity via pericyte dysfunction.

Authors: Ryota Nakazato, Kenji Kawabe, Daisuke Yamada, Shinsuke Ikeno, Michihiro Mieda, Shigeki Shimba, Eiichi Hinoi, Yukio Yoneda and Takeshi Takarada

Year of Publication: 2017


Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067


Bmal1, homeostasis, sleep disorders

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