Elucidated causes of the acceleration of development of new rotavirus and reduced vaccination effect through genomic analysis of rotavirus isolated in India

October 27(Fri), 2017

Professor Emeritus Sumio Shinoda of Okayama University, who served as the former director of the Collaborative Research Center of Okayama University for Infectious Diseases in India, Associate Professor Daisuke Imamura, and Professor Kazuhiko Katayama of Kitasato University (former laboratory director at the National Institute of Infectious Diseases) identified the factors of the establishment and spread of atypical virus strains, the influence of vaccines, etc. through whole genome analysis of isolated strains of rotavirus in India. The result of this research was published in the science magazine Infection, Genetics and Evolution on July 25.

Unhygienic environments where patients can be simultaneously infected with multiple strains of rotaviruses of different genotypes cause a decrease in vaccination efficacy and an increase in the emergence of new types of viruses. In developing countries such as India, rotavirus among the young population is a major diarrheal pathogen, and thus it is necessary to conduct continuous analyses and trend studies of the virus to prevent it from spreading.


Article Information

DOI: doi.org/10.1016/j.meegid.2017.07.025
Authors: Yen Hal Doan, Yoshiyuki Suzuki, Yoshiki Fujii, Kei Haga, Akira Fujimoto, Reiko Takai-Todaka, Yuichi Someya, Mukti K. Nayak, Anupam Mukherjee, Daisuke Imamura, Sumio Shinoda, Mamta Chawla-Sarkar and Kazuhiko Katayama.
Journal: Infection, Genetics and Evolution
Title: Complex reassortment events of unusual G9P{4} rotavirus strains in India between 2011 and 2013.
Year of Publication: 2017                                                                                                                    Volume: 54, 417- 428


Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067

E-mail:    ousvo@okayama-u.ac.jp


rotavirus, developing country

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