Evolution of Vibrio cholerae O1 epidemic strains revealed in comparative genomics

May 25(Thu), 2017

Professor Shinichi Miyoshi, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Social and Environmental Science, leads a research group collaborating with other institutions including the National Institute of Infectious Diseases to analyze the genomes of 80 strains of Vibrio cholerae O1 isolated between 2007 to 2014 from patients in Kolkata, India, a center of cholera epidemics. Through comparative genomic analysis of genome data, they found that the predominant strain shifted to a virulent strain in 2010 and has continued to mutate since then. Their results suggest that there are frequent shifts in the predominant strain causing cholera in Kolkata, which experiences annual epidemics of cholera. The results of the group’s research were published in the American online journal PLoS Neglected Tropical Diseases on February 13.
In the future, the group plans to conduct similar comparative genomic analyses of V. cholerae O1 isolated from environmental water such as rivers and ponds and surrounding countries such as Bangladesh to determine how predominant strains come to develop and by what routes they propagate. They also plan to create a database of the genomic data for V. cholerae O1 they collected and publish it online to share the data widely and promote its active utilization.

Article Information

DOI: 10.1371/journal.pntd.0005386

Journal: PLoS Neglected Tropical Deseases

Title: Comparative genome analysis of VSP-II and SNPs reveals heterogenic variation in contemporary strains of Vibrio cholerae O1 isolated from cholera patients in Kolkata, India.

Year of Publication: 2017

Volume: 11

Issue: 2

Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.
Phone: (1)510-468-3372
E-mail: ousvo@okayama-u.ac.jp
VSP-II , SNPs, Vibrio cholerae O1, cholera

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