It Has Been Revealed that PIK3RI Germline Mutation in Glioblastoma Correlates with CCN1 Protein, Responsible for the Formation of Blood Vessels, Expression and Prognosis

August 07(Mon), 2017

A team of researchers led by Senior Assistant Professor Kazuhiko Kurozumi, Clinical fellow Yoshihiro Otani of Department of Neurological Surgery at Okayama University, and Professor Isao Date of Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, has revealed that in glioma, a type of brain tumor (especially in glioblastoma), PIK3RI gene’s germline mutation correlates with prognosis and expression of cysteine-rich protein 61 (CCN1) that is responsible for the formation of blood vessel that conveys nutrition to the tumor, cell growth, and tumor infiltration. The research output was published online with Scientific Reports, a British scientific journal, at 10 a.m. on August 7th, UK time (6 p.m. JST).

As there is no medication for complete cure of malignant glioma, various researches are being conducted at both fundamental and clinical levels. Drug development focusing on mutating genes is expected to produce more individualized treatments.


Article Information

DOI: 10.1038/s41598-017-07745-0

Journal: Scientific Reports

Title: PIK3R1 Met 326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma

Authors: Yoshihiro Otani, Joji Ishida, Kazuhiko Kurozumi, Tetsuo Oka, Toshihiko Shimizu, Yusuke Tomita, Yasuhiko Hattori, Atsuhito Uneda, Yuji Matsumoto, Hiroyuki Michiue, Shuta Tomida, Takehiro Matsubara, Tomotsugu Ichikawa & Isao Date

Year of Publication: 2017


Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067


PIK3RI gene, protein 61, CCN1, 326Ile

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