Predictions of relapse of ANCA-associated vasculitis can now be made! – Looking at MPO-ANCA positive conversions

June 29(Fri), 2018

ANCA-associated vasculitis is an intractable disease which is caused by an abnormal antibody, ANCA, which targets neutrophil (a type of leukocyte). It damages tiny blood vessels and causes the failure of multiple organs. The number of patients who are affected by it is increasing, especially among the elderly.

Haruki Watanabe, an assistant professor, and Ken-ei Sada, an associate professor, both from Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, and Masayoshi Harigai, a specially appointed professor at Tokyo Women’s Medical University, discovered the importance of measuring the level of the autoantibody MPO-ANCA against the enzyme protein myeloperoxidase (MPO), which is included in the cell cytoplasm of neutrophil during the process of improving the prognosis of ANCA-associated vasculitis.

The level of MPO-ANCA can be checked with a blood test at a medical facility, and it was found in this research that a patient who experiences a positive conversion of MPO-ANCA during treatment of ANCA-associated vasculitis has a 26-times higher chance of relapse than a patient who stays negative.

This research accomplishment was published as an Original Article in Arthritis & Rheumatology, the official journal of the American College of Rheumatology, on May 22, 2018. It was also reported on by Wiley’s Research Headlines, a news website.

This research finding suggests periodic checking of the MPO-ANCA levels can help predict a relapse of ANCA-associated vasculitis, and can be useful in improving patients’ life prognoses and quality of life.

Article Information

DOI: 0.1002/art.40538.
Journal: Arthritis & Rheumatology
Authors: Haruki Watanabe, Ken-Ei Sada, Yoshinori Matsumoto, Masayoshi Harigai, Koichi Amano, Hiroaki Dobashi, Shouichi Fujimoto, Joichi Usui, Kunihiro Yamagata, Tatsuya Atsumi, Shogo Banno, Takahiko Sugihara, Yoshihiro Arimura, Seiichi Matsuo, Hirofumi Makino, For Japan Research Committee of the Ministry of Health Labour,Welfare for Intractable Vasculitis (JPVAS) Research Committee of Intractable Renal Disease of the Ministry of Health Labour, Welfare of Japan
Title: Association between reappearance of myeloperoxidase‐antineutrophil cytoplasmic antibody and relapse in antineutrophil cytoplasmic antibody‐associated vasculitis: Subgroup analysis of nationwide prospective cohort studies
Year of Publication: 2018

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