Revealing the fact that female hormones can attenuate the spinal neural circuit that controls male sexual functions

May 31(Thu), 2018

A collaborative research group consisting of Hirotaka Sakamoto, an associate professor at the Graduate School of Natural Science and Technology (Science), Okayama University, Osamu Ukimura, a professor at the Department of Urology, Kyoto Prefectural University of Medicine, and Bukkyo University discovered that progesterone (1), a female hormone, attenuates the male sexual function circuit existing in the spinal cord of mammals.
These results were published in the U.S. scientific magazine “Endocrinology” on April 1, 2018.
Prior to this research, it was unclear how female hormones affected the neural circuit of male sexual functions. During this research, it became clear that in the spinal cord of a male rat, progesterone was attenuating the neural circuit of male sexual functions. Further studies with cultivated cells revealed that the same applies to humans, too.
It is widely known that sex hormones and reproductive behaviors are closely related. In this study, the neural circuit formation mechanism that is specific to male sexual functions became clear. It is expected to contribute to the improvement of gender-specific medicine.

Article Information
DOI: 10.1210/en.2018-00043
Authors: Takumi Oti, Keiko Takanami, Saya Ito, Takashi Ueda, Ken Ichi Matsuda, Mitsuhiro Kawata, Jintetsu Soh, Osamu Ukimura, Tatsuya Sakamoto and Hirotaka Sakamoto
Journal: Endocrinology
Title: Effects of sex steroids on the spinal gastrin-releasing peptide system controlling male sexual function in rats.
Year of Publication: March, 2018 Volume: 159(4), pp1886-1896

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