Succeeded in regeneration of dog’s teeth Prove the feasibility of perfect dental regeneration treatment in humans due to successful structured and functionally complete tooth regeneration in large animal models

March 14(Tue), 2017

Takuo Kuboki, Professor at Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Masamitsu Oshima, Assistant Professor at the department, and Mitsuaki Ono, Assistant Professor at Department of Molecular Biology and Biochemistry at the graduate school, Takashi Tsuji, Team Leader at Center For Developmental Biology, the Institute of Physical and Chemical Research (RIKEN), and others have demonstrated whole-tooth regeneration in a large-animal model (beagle) by using a bioengineering technique (called organ germ transplantation) that allows regeneration of an organ from an organ germ (organ bud).  The bioengineered tooth has the same structure and functions as those of a natural tooth.


This study was reported in the international journal Scientific Reports at 10 a.m. British Time (7 p.m. Japan Time) on March 16.  This study is deemed to be a translational research path toward feasibility study of future tooth regeneration therapy, and is promising for development of organ regeneration therapy applicable to various organs such as secretory glands and hair.

Article Information

DOI: 10.1371/journal.pntd.0005386

Authors: Mitsuaki Ono, Masamitsu OshimaMiho Ogawa, Wataru SonoyamaEmilio Satoshi HaraYasutaka OidaShigehiko ShinkawaRyu Nakajima, Atsushi MineSatoru Hayano, Satoshi FukumotoShohei Kasugai, Akira YamaguchiTakashi Tsuji, Takuo Kuboki

Journal: Scientific Report

Title: Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model

Year of Publication: 2017

Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.
Phone: (1)510-468-3372
tooth regeneration therapy, organ regeneration therapy

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