Succeeded in regeneration of dog’s teeth Prove the feasibility of perfect dental regeneration treatment in humans due to successful structured and functionally complete tooth regeneration in large animal models
March 14(Tue), 2017
Takuo Kuboki, Professor at Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Masamitsu Oshima, Assistant Professor at the department, and Mitsuaki Ono, Assistant Professor at Department of Molecular Biology and Biochemistry at the graduate school, Takashi Tsuji, Team Leader at Center For Developmental Biology, the Institute of Physical and Chemical Research (RIKEN), and others have demonstrated whole-tooth regeneration in a large-animal model (beagle) by using a bioengineering technique (called organ germ transplantation) that allows regeneration of an organ from an organ germ (organ bud). The bioengineered tooth has the same structure and functions as those of a natural tooth.
This study was reported in the international journal Scientific Reports at 10 a.m. British Time (7 p.m. Japan Time) on March 16. This study is deemed to be a translational research path toward feasibility study of future tooth regeneration therapy, and is promising for development of organ regeneration therapy applicable to various organs such as secretory glands and hair.
Authors: Mitsuaki Ono, Masamitsu Oshima, Miho Ogawa, Wataru Sonoyama, Emilio Satoshi Hara, Yasutaka Oida, Shigehiko Shinkawa, Ryu Nakajima, Atsushi Mine, Satoru Hayano, Satoshi Fukumoto, Shohei Kasugai, Akira Yamaguchi, Takashi Tsuji, Takuo Kuboki
Journal: Scientific Report
Title: Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model
Year of Publication: 2017
Okayama University Silicon Valley Office (OUSVO)
|Contact:||Mototaka Senda, Ph.D.|
- tooth regeneration therapy, organ regeneration therapy