Successful inhibition of cancer invasion and metastasis by targeting the PEX isoform / MMP3

May 31(Thu), 2018

A research group consisting of Drs Yuka Okusha, Takanori Eguchi, and colleagues at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences successfully inhibited cancer invasion and metastasis at an animal experiment level.
Matrix metalloproteinase 3 (MMP3) had been known as an extracellular proteolytic enzyme that can cleave and degrade extracellular proteins, but this research group originally have demonstrated intracellular roles for MMP3. In this study, this group firstly performed transcriptome analysis of rapidly and slowly metastatic colon cancer cells and then newly found a non-proteolytic isoform of MMP3 was produced from rapidly metastatic colon cancer- designated the PEX isoform. The PEX isoform / MMP3 was expressed at marginal area of tumors and tumor microenvironment, where this isoform can promote growth and migration of cancer cells leading to their metastasis.
This research accomplishment was published in the online version of the “Journal of Cellular Biochemistry” on May 15, 2018.

Article Information

DOI: 10.1002/jcb.27040
Authors: Yuka Okusha, Takanori Eguchi, Chiharu Sogawa, Tatsuo Okui, Keisuke Nakano, Kuniaki Okamoto, and Ken-ichi Kozaki
Journal: Journal of Cellular Biochemistry
Title: The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells
Year of Publication: May 2018

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