Successful Synthesis of Sulfo-sialic Acid Derivatives as Leads for the Development of Anti-influenza Drugs

September 28(Thu), 2017

The joint research group of Professor Hiromasa Kiyota of Okayama University Graduate School of Environmental and Life Science (Agriculture), together with researchers at Kobe University, has successfully synthesized sulfo-sialic acid derivatives that can lead to the development of new anti-influenza drugs. This research result was published in the British scientific journal Scientific Reports as a research article on August 15.

The article by Vavricka et al. showed that the synthetic sulfo-sialic acid derivatives are more potent inhibitors of the influenza virus neuraminidase enzyme as compared to the carboxy type or phosphono type compounds.  This study proves the concept that the sulfo groups will be a key modification for the development of next-generation anti-influenza drugs.

 

Article Information

DOI: 10.1038/s41598-017-07836-y

Journal: Scientific Reports

Title: Synthesis of Sulfo-Sialic Acid Analogues: Potent Neuraminidase Inhibitors in Regards to Anomeric Functionality

Authors: Christopher J. Vavricka, Chiaki Muto, Tomohisa Hasunuma, Yoshinobu Kimura,Michihiro Araki, Yan Wu, George F. Gao, Hiroshi Ohrui, Minoru Izumi, Hiromasa Kiyota

Year of Publication: 2017

 

Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067

E-mail:    ousvo@okayama-u.ac.jp

Keyword:
Anti-influenza Drugs, Sulfo-Sialic Acid,

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