The Anti Osteoporosis Drug Clodronate is Effective for Chronic Pain Treatment! World-first Discovery of Its Mechanism

July 19(Wed), 2017

A collaborative research group of Specially Appointed Assistant Professor Yuri Kato and Associate Professor Takaaki Miyaji of the Advanced Science Research Center, Okayama University, together with the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University, Matsumoto Dental University, Kurume University, Tohoku University, Kyushu University, Tokyo University of Agriculture and Ajinomoto Co., Inc. has discovered for the first time in the world that inhibition of the transporter (VNUT) that transports ATP to vesicles by the anti-osteoporosis drug clodronate can contribute to alleviation of neuropathic, inflammatory and other chronic pain. The research results were published in the electronic version of “Proceedings of the National Academy of Sciences of the United States of America (PNAS)” at noon on July 18th, 2017 in the U.S.

It is said that 20 to 25% of the world’s population suffers from chronic pain, but effective analgesic drugs with little side effects have yet to be developed. With these research results, we are able to offer a completely new type of analgesic and anti-inflammatory drug that targets a particular transporter. Clodronate is approved for clinical use in many European countries and the U.S., and its clinical safety in humans is well established. Drug repositioning can help shorten the length of the development period and lower development costs, so we can expect the research results to provide benefits to society soon.


Clodronate-evoked inhibition of vesicular ATP release is important for the treatment of chronic pain. 




Article Information

DOI: 10.1073/pnas.1704847114

Journal: Proceedings of the National Academy of Sciences of United States of America

Title: Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain

Authors: Yuri Kato, Miki Hiasa, Reiko Ichikawa, Nao Hasuzawa, Atsushi Kadowaki, Ken Iwatsuki, Kazuhiro Shima, Yasuo Endo, Yoshiro Kitahara, Tsuyoshi Inoue, Masatoshi Nomura, Hiroshi Omote, Yoshinori Moriyama, Takaaki Miyaji.

Year of Publication: 2017


Okayama University Silicon Valley Office (OUSVO)

Contact:   Mototaka Senda, Ph.D.

Phone:      (1)510-894-3067









VNUT, ATP, chronic pain, Anti Osteoporosis Drug

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