The Bursting of Cartilage Cells Provides Opportunities for Bone Formation! Discovery of a New Mechanism of Bone Formation

January 17(Wed), 2018

A collaborative research group, consisting of Emilio Hara, Assistant Professor, and Takuya Matsumoto, Professor, at the Department of Biomaterials in the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences at Okayama University, with Osaka University, discovered a new mechanism of bone formation using a mouse model.

This new mechanism can be observed in the initial stage of bone tissue formation at the joint of a bone, such as a femur, which is called the secondary ossification center. The research group found that as a result of chondrocytes in this area being enlarged, some of the cells burst, creating space that is needed for bones to be formed, and that nanofragments of the cell membranes remaining after this burst can be the starting point of bone mineralization.

The research group further discovered that this bursting of cells is caused by mechanical pressure, such as during walking. These discoveries will lead to understanding a suitable environment for bone growth and to the development of new biomaterials for bone regeneration. These accomplishments were published in the U.S. science magazine ACS Biomaterials Science & Engineeringat midnight on January 17, 2018, Japan Standard Time (10 a.m. on the 16thin the U.S.) and on the online version of the British science magazine Integrative Biologyat 10 p.m. on January 15, 2018, Japan Standard Time (1 p.m. in England).

 

Article Information

DOI:10.1021/acsbiomaterials.7b00962

Authors: Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto

Journal:ACS Biomaterials Science & Engineering

Title: Bioinspired mineralization using chondrocyte membrane nanofragments

Year of Publication:2018

Volume:4(2), pp617-625

 

DOI:10.1039/c7ib00130d

Authors: Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto

Journal:Integrative Biology

Title: Chondrocyte burst promotes space for mineral expansion

Year of Publication:Jan 22, 2018

Volume:10(1): 57-66

 

Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067

E-mail:    ousvo@okayama-u.ac.jp

 

 

 

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