Understanding the factor that controls and adjusts both bone formations and adipocyte differentiations
March 22(Thu), 2018
An international research collaborative group consisting of Hirohiko Okamura, Professor (Department of Oral Morphology), Mika Ikegame, Associate Professor, Kenta Uchibe, Assistant Professor at the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University, Kaya Yoshida (Department of Oral Healthcare Education), Instructor at the Department of Histology and Oral Histology, Institute of Biomedical Sciences at the Tokushima University Graduate School, and the Department of Endodontics, School of Stomatology, China Medical University (Shenyang, Liaoning Province, China), analyzed the factor which is expressed in osteoblast cells and adjusts both bone formations and adipocyte differentiations. The team found that protein phosphatase 2A Cα (“PP2A”) has an important role in those functions. This research result was published in the European science magazine “Molecular and Cellular Endocrinology” on November 8, 2017.
In this research, it has become clear that in addition to adjusting bone mass and bone density, PP2A also controls regulating factors for adipocyte differentiation that are secreted by osteoblast cells. Understanding PP2A’s functions and mechanism in bone formations and fat development in detail is expected to offer important knowledge in developing the prevention of osteoporosis in aging societies and fatty degeneration in bone marrow (*3).
Authors: Kaya Yoshida, Jumpei Teramachi, Kenta Uchibe, Mika Ikegame, Lihong Qiu, Di Yang, Hirohiko Okamura
Journal:Molecular and Cellular Endocrinology
Title: Reduction of protein phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation.
Year of Publication:Nov 8, 2017
Okayama University Silicon Valley Office (OUSVO)
Contact: Mototaka Senda, Ph.D.