Visual Evoked Potential Improved with Okayama University-type Retinal ProsthesisOUReP™in Monkey Eyes with Macular Degeneration – Proving the Effectiveness of OUReP™and Accelerating the Establishment of Doctor-led Clinical Trials –

January 26(Fri), 2018

A medical and engineering collaborative research team of Toshihiko Matsuo, Associate Professor at the Department of Ophthalmology in the Graduate School of Medicine, Dentistry and Pharmaceutical Sciences at Okayama University (medical), Tetsuya Uchida, Associate Professor atthe Department of Polymer Materials Science inthe Graduate School of Natural Science and Technology at Okayama University (engineering), Kunihisa Kamikawa, Professor, and Jun Sakurai, Associate Professor, at the Center for Innovative Clinical Medicine in Okayama University Hospital, demonstrated that the visual evoked potential of a monkey with macular degeneration could recover with the “Okayama University-type retinal prosthesisOUReP™.” The study also indicated that implantation of theretinal prosthesis OUReP™to a monkey was performed safely through vitreous surgery, and the condition of the monkey had been stable for six months after the surgery without any complications. The results of this research will soon be published in “Artificial Organs,”a journal of the American Society for Artificial Internal Organs.

The Okayama University-type retinal prosthesisOUReP™  is a dye-coupled thin film prosthetic retina and is completely different from the type of prosthetic retinas with camera image processing or electrode arrays that began sales in the U.S. in 2013, making OUReP™the “world’s first new format” of retinal prosthesis. Currently, discussions with the Pharmaceuticals and Medical Devices Agency (PMDA) are being held to proceed with a doctor-led clinical trial to be held at Okayama University Hospital in accordance with the Act on Pharmaceuticals and Medical Devices (formerly the Pharmaceutical Affairs Act).

A retinal prosthesis as a clinical trial device needs to be extremely safe, effective and of a high quality. Just because there are research seeds available now, it does not mean that the product can be used immediately on actual patients. There are many tests that must be conducted properly over a long period of time. This research result showing the effectiveness and safety of a prosthetic retinahas put us one step closer to a doctor-led clinical trial.

 

Article Information

DOI:

Authors: Matsuo T, Uchida T, Sakurai J, Yamashita K, Matsuo C, Araki T, Yamashita Y, Kamikawa K.

Journal:Artificial Organs

Title:Visual evoked potential recovery by subretinal implantation of photoelectric dye-coupled thin film retinal prosthesis (OURePTM) in monkey eyes with macular degeneration.

Year of Publication:2018

Volume:42

 

DOI:https://doi.org/10.1292/jvms.17-0450

Authors: Matsuo T, Uchida T, Nitta M, Yamashita K, Takei S, Ido D, Tanaka M, Oguchi M, Furukawa T.

Journal:Journal of Veterinary Medical Science

Title: Subretinal implantation of Okayama University-type retinal prosthesis (OURePTM) in canine eyes by vitrectomy.

Year of Publication:2017

Volume:Volume 79 (2017), Issue 12, Pages 1939-1946.

 

DOI:https://doi.org/10.1292/jvms.17-0422

Authors: Matsuo T, Uchida T, Yamashita K, Takei S, Ido D, Tanaka M, Oguchi M, Furukawa T.

Journal:Journal of Veterinary Medical Science

Title: Visual evoked potential in rabbits’ eyes with subretinal implantation by vitrectomy of Okayama University-type retinal prosthesis (OURePTM).

Year of Publication:2018

Volume:80(2018), Issue 2, Pages 247-259

 

Okayama University Silicon Valley Office (OUSVO)

Contact: Mototaka Senda, Ph.D.

Phone:    (1)510-894-3067

E-mail:    ousvo@okayama-u.ac.jp

 

Back to List